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Newsletter
June 10, 2006
Volume VII, Issue 48
Home Page : www.otcjournal.com
Email Questions or Comments To: editor@otcjournal.com

To OTC Journal Members:
 

Advance Cell Technology (OTC BB: ACTC); Oversold and Under Appreciated

I decided to take another look at Advanced Cell this weekend. This stock is absurdly oversold, and could be poised to bounce off current levels. Overly victimized in the recent market carnage, it could be easy money for bargain basement shoppers.

The key issue here is Stem Cell technology. The market has forgotten about Stem Cells in lieu of all the other headline generators- i.e. War with Iraq, skyrocketing oil and gold, and inflation (increasing interest rates).

Stem Cells still hold out the promise to represent true "cures" for the diseases and other health problems that plague mankind. Human embryonic stem cells are the first cultured in the laboratory capable of becoming every cell type in the human body. These little guys don't simply provide therapy to damaged cells- they have the ability to go in and literally "replace" damaged or diseased cells with new, healthy ones.

Let's review Advanced Cell's unique technology:

ACTC is focusing on Stem Cell therapies for three maladies: 1. Age related eye diseases 2. Heart repair and blood disorders, and 3. Dermal repair for burn victims and skin disease. The company has selected these three areas because there is unlimited demand for better therapies, and they have made the most progress in the clinic in these treatments. They are expected to file their IND with the FDA for eye disease in just over one year, with the other two IND's to follow in 2008.

If proven successful, these treatments won't be new drugs that provide temporary relief or some small measure of improvement (like a new cancer drug that extends life expectancy by 10%). Stem Cell therapy has the potential to represent real cures. Stem Cells have the ability to differentiate into new, healthy cells, thereby providing the potential to replace the damaged, non-functioning cells. Hence the term "Regenerative Medicine"- healthy cells are literally regenerated and replace damaged cells.

Here's a graphic that demonstrates a simplified version of the ACTC process. It all starts with an eight cell entity called a "Blastocyst". A Blastocyst can be derived from any human egg, often donated or obtained from an IVF (invitro fertilization clinic).

Scientists at ACTC can extract pluripotent stem cells from a Blastocyst, and cultivate them. A pluripotent stem cell can morph into any kind of cell in the human body.

Through "Differentiation" scientists at ACTC coach Stem Cells to naturally develop into specific cells to be used as therapies for various specific ailments. 

Now- here's the part that blew my mind: Here's how the scientists at ACTC are dealing with compatibility issues. The blastocyst comes from a human egg. The human egg can be infused with anyone's DNA, including yours. From there, the scientists can create a Stem Cell line perfectly matched to your DNA without damaging the egg. In theory, somewhere down the road, your own fetal stem cells can be recreated and used to restore any damaged cells in your body, whether it be disease (i.e. Parkinson's, Alzheimer's, cancer) or accidental (burn victims, spinal injuries, torn up knees). 

In fact, last year the scientists at ACTC were able to infuse a mouse's egg with DNA, extract a single Blastomere, re-implant the egg, and a healthy mouse was born. The event was covered in a feature article in the NY Times, and you can access the article and read it by simply Clicking Here.

This science has multi billion dollar potential, and for investors who want a piece of the future of Stem Cells in a microcap stock, this is one of the most exciting situations you will find. Their science alone is worth far more than the meager $22 million market value the company currently sports.

In my view, it is simply a question of waiting until the market pendulum swings back to the Stem Cell sector. Inevitably, it will, since Stem Cell therapy represents potential breakthroughs unlike any other technology being explored in the biotech world. Stem Cell companies will probably re-emerge on the Wall Street radar screens in the Fall in conjunction with the $3 billion bond offering for funding Stem Cell research in California. It is currently bogged down in the legal systems, but most observers believe the legal path should be clear in Q4 of '06.

The chart I've decided to use today contains a technical measure called a "stochastic". This wave is a good method for determining if a stock is technically oversold. Historically, every time the stochastic level has dropped to zero, the stock has rebounded and moved up. 

As covered exhaustively in past editions, the financiers of this company are awarded $750,000 worth of free trading shares every month, which leads to fairly predictable sell offs. This month's "ration" has had an exaggerated effect on the stock price thanks to the drubbing the market has taken. A kind of "piling on" if you will.

Two of the industries most high profile pioneers- Dr. Michael West, the founder of Geron (NASDAQ: GERN), and Dr. Robert Lanza, author of 16 books in his field, direct their efforts. These guys have pedigrees which lend themselves to companies far beyond $.85 microcap stocks. 

Moreover, this little company's science has already been covered in two NY Times feature articles. The main stream press knows about them.

It is a contrarian idea. Stocks are out of favor, and I haven't heard the phrase "Stem Cells" muttered on CNBC for months now. This is a multi year idea- one to put in the long term speculative portfolio and forget about. However, from current levels, it could be a short term trade as well. 

From here, a $.75 SSL (suggested stop loss) should be considered.
 

Comments in the BLOG
 

Another miserable week has passed in the markets. If you are like most investors, you are generally on the long side and feeling some pain. If you are in all cash or short, you have been having a ball watching the market melt down over the past three weeks. Post the jobs report last Friday, it would appear from the current "FED Speak" that one and done is off the table for interest rate increases. It is now a near certainty there will be another 1/4 point rate hike later in June, and no end in sight. If you think the US market is bad, some of the world wide emerging markets are really getting killed. The May 21st Edition entitled Don't Say You Weren't Warned is unfortunately looking prophetic now.

No new Blogs since NWWV this past Wednesday. The one shining star in an otherwise bleak sky. 

To use the BLOG, simply go to the home page at www.otcjournal.com - the BLOG will scroll down automatically on the right side of your screen. The most current journal entries appear in the middle of your screen. Check back frequently for updates particularly when stocks are moving to overbought or oversold levels in volatile markets.
 

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